Browsing Biochemistry by Date of Publication
Now showing items 21-40 of 1015
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Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
(The American Society for Biochemistry and Molecular Biology, 1990)The post-receptor events which follow the binding of interleukin 1 (IL1) to cells are unclear. The present studies provide evidence for the activation of a guanine nucleotide binding protein (G protein) by IL1 in the ... -
Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus
(SGM, 1991)Immunization of BALB/c mice with a single dose of the Sabin type 1, type 2 or type 3 poliovirus vaccine strains stimulated cross-reactive T helper cell responses detected by both in vitro proliferation and interleukin ... -
Kinetics of the barotropic ripple (P beta')/lamellar liquid crystal (L alpha) phase transition in fully hydrated dimyristoylphosphatidylcholine (DMPC) monitored by time-resolved x-ray diffraction.
(1991)We present here the first study of the use of a pressure-jump to induce the ripple (P,.)/lamellar liquid crystal (Lj phase transition in fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The transition ... -
Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction.
(1992)In many lipid systems, polymorphic and mesomorphic behavior depends on sample thermal history. To establish unequivocally the structural origin of endothermic and exothermic events in such systems, we have performed ... -
Calorimetric and x-ray diffraction studies of rye glucocerebroside mesomorphism
(1992)Glucocerebrosides (GlcCer) isolated from the leaves of winter rye (Secale cereale L. cv Puma) differ from the more commonly investigated natural and synthetic cerebrosides, in that greater than 95% of the fatty acids are ... -
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.
(The American Society for Biochemistry and Molecular Biology, 1992)It is not known whether one or both of the interleukin 1 (IL1) receptors mediates the induction of the DNA-binding protein NF-kappa B. Nuclear extracts of the murine lines EL4.NOB.1 and 70Z/3, which bear the type I (80 ... -
Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain.
(1992)White Leghorn hens were immunized with enterotoxigenic Escherichia coli B16-4 with heat-labile enterotoxin and colonization factor antigen I in Freund's adjuvant. Specific antibodies were detected by an enzyme-linked ... -
Cellular immunity in pertussis
(The Pathological Society of Great Britain and Ireland, 1993) -
Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model
(American Society for Microbiology, 1993)A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to ... -
Interleukin-1 activates transcription factor NF kappa B in glial cells
(Portland Press, 1993)Recombinant human interleukin-1 (IL-1) alpha and beta were found to activate a latent cytosolic form of the transcription factor NF kappa B in rat C6 glioma. IL-1 beta was 10 times more potent than IL-1 alpha for this ... -
Effective immunization against Bordetella pertussis respiratory infection of mice is dependant on the induction of cell mediated immunity
(American Society for Microbiology, 1993)A murine respiratory challenge model was used to examine the induction of cellular and humoral immune responses and their role in protection against Bordetella pertussis following immunization or previous infection. Spleen ... -
Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit.
(The American Society for Biochemistry and Molecular Biology, 1995)The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat ... -
Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes.
(Taylor and Francis, 1995)Bromodeoxyuridine incorporation is a useful method for studying the pattern of DNA synthesis in proliferating cells. The distribution pattern of incorporated BrdU in villus enterocytes of duodenal explants was analysed ... -
Signalling via CD28 of human naive neonatal T lymphocytes.
(British Society for Immunology, 1995)Accessory molecules play a crucial role in the development of the T cell response to antigenic challenge. We have examined the role of CD28 in modulating the 'naive' neonatal T cell response to anti-CD2-mediated activation. ...