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dc.contributor.authorHOLLAND, CELIAen
dc.contributor.authorSTAFFORD, PETERen
dc.date.accessioned2011-06-03T14:24:50Z
dc.date.available2011-06-03T14:24:50Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationDold, C., Cassidy, J.P., Stafford, P., Behnke, J.M. and Holland, C.V., Genetic influence on the kinetics and associated pathology of the early stage (intestinal-hepatic) migration of Ascaris suum in mice, Parasitology, 137, 2010, 173 - 185en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/56374
dc.descriptionPUBLISHEDen
dc.description.abstractThe generative mechanism(s) of aggregation and predisposition to Ascaris lumbricoides and A. suum infections in their host population are currently unknown and difficult to elucidate in humans and pigs for ethical/logistical reasons. A recently developed, optimized murine model based on 2 inbred strains, putatively susceptible (C57BL/6j) and resistant (CBA/Ca) to infection, was exploited to elucidate further the basis of the contrasting parasite burdens, most evident at the pulmonary stage. We explored the kinetics of early infection, focusing on the composite lobes of the liver and lung, over the first 8 days in an effort to achieve a more detailed understanding of the larval dispersal over time and the point at which worm burdens diverge. Larval recoveries showed a heterogenous distribution among the lobes of the lungs, being higher in the right lung of both strains, and in the susceptible strain larvae accumulating preferentially in 2 (caudal and middle) of the 4 lobes. Total larval burdens in these 2 lobes were largely responsible for the higher worm burdens in the susceptible strain. While total lung larval recoveries significantly differed between mouse strains, a difference in liver larval burdens was not observed. However, an earlier intense inflammatory response coupled with more rapid tissue repair in the hepatic lobes was observed in CBA/Ca mice, in contrast to C57BL/6j mice, and it is possible that these processes are responsible for restricting onward pulmonary larval migration in the resistant genotype.en
dc.format.extent173en
dc.format.extent185en
dc.language.isoenen
dc.relation.ispartofseriesParasitologyen
dc.relation.ispartofseries137en
dc.rightsYen
dc.subjectAscaris lumbricoidesen
dc.subjectInfectious Diseasesen
dc.subjectAscaris suumen
dc.titleGenetic influence on the kinetics and associated pathology of the early stage (intestinal-hepatic) migration of Ascaris suum in miceen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/chollanden
dc.identifier.rssinternalid59811en
dc.contributor.sponsorGrantNumber06/RFP/EEB009en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://dx.doi.org/10.1017/S0031182009990850en


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