Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds
Citation:
James W. Barlow, Aengus P. McHugh, Orla Woods, John J. Walsh, Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds, European Journal of Medicinal Chemistry, 46, 5, 2011, 1545-1554Download Item:
Abstract:
In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo.
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http://people.tcd.ie/jjwalshDescription:
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Author: WALSH, JOHN JARLATH
Publisher:
ElsevierType of material:
Journal ArticleSeries/Report no:
European Journal of Medicinal Chemistry;46;
5;
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Full text availableKeywords:
Biochemistry and molecular biology, mast cellMetadata
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