Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent
Citation:
Adam J. Byrne, James W. Barlow, John J. Walsh, Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent, Bioorganic & Medicinal Chemistry Letters, 21, 4, 2011, 1191-1194Download Item:
Abstract:
Each stereoisomer of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, 1a-d, was prepared and evaluated in vitro for its ability to prevent mediator release induced by different degranulating agents from rodent mast cells and also in vivo against passive cutaneous anaphylaxis. The manner in which the stereoisomers prevented direct membrane activation was found to be highly dependent on the stereochemistry of the individual isomers. Stereoisomer 1b was the most active isomer in vivo, exhibiting superior activity to disodium cromoglycate.
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Enterprise Ireland
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http://people.tcd.ie/jjwalshDescription:
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Author: WALSH, JOHN JARLATH
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ElsevierType of material:
Journal ArticleSeries/Report no:
Bioorganic & Medicinal Chemistry Letters;21;
4;
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Medicinal chemistry, Mast cellsMetadata
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