Browsing School of Medicine by Author "Walsh, Patrick"
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Advancing the therapeutic potential of the IL-1 family in inflammatory diseases - Meeting report
Walsh, Patrick (2019)On October 9th 2018 the Trinity College Dublin hosted a workshop forum at the Royal Irish Academy to discuss recent discoveries and current areas of focus in the field of IL‐1 family biology. The aim of this meeting was ... -
Current perspectives on the interleukin-1 family as targets for inflammatory disease.
Walsh, Patrick; Lucitt, Margaret (2019)Since the first description of interleukin-1 (IL-1) and the genesis of the field of cytokine biology, the understanding of how IL-1 and related cytokines play central orchestrat- ing roles in the inflammatory response has ... -
Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines.
Walsh, Patrick; Doyle, Sarah; Brennan, Kiva (2022)Pattern recognition receptors (PRRs) of the innate immune system represent the critical front-line defense against pathogens, and new vaccine formulations target these PRR pathways to boost vaccine responses, through ... -
Human β-Defensin 3 and Its Mouse Ortholog Murine β-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice
Walsh, Patrick; Tobin, Anne-Marie (2016) -
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
Walsh, Patrick; Long, Aideen; Fallon, Padraic (2022)IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate ... -
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
Walsh, Patrick; Doyle, Sarah; Fallon, Padraic (2019)Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a ... -
Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by ?? T Cells.
Walsh, Patrick; Fallon, Padraic (2013)Expression of the orphan receptor Toll IL-1R8/single Ig IL-1–related receptor has been reported to be reduced in the peripheral blood of psoriatic arthritis patients. However whether TIR8/SIGIRR activity plays a specific ...