Browsing School of Medicine by Title
Now showing items 2234-2253 of 3151
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P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction Paediatric mild traumatic brain injury (mTBI) is increasingly recognised to have significant longer term neurocognitive effects. Childhood is a time of high risk for head injury. There were no national ... -
Pain management in children and young adults with minor injury in emergency departments in the UK and Ireland: a PERUKI service evaluation
(2022)Background: Management of acute pain should commence at the earliest opportunity, as it has many short-term and long-term consequences. A research priority of Paediatric Emergency Research in the UK and Ireland (PERUKI) ... -
Pain-related Disability, Physical Function and Behavioural Aspects of Ankylosing Spondylitis-related Inflammatory Low Back Pain
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2019)Inflammatory low back pain (ILBP) is a key clinical symptom and a significant problem in ankylosing spondylitis (AS), and its high socioeconomic costs are mainly attributed to disability. Ankylosing spondylitis-related ... -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Palliative care in the era of novel oncological interventions: needs some "tweaking"
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS)
(2016)Clinically relevant postoperative pancreatic fistula (grades B and C of the ISGPS definition) remains the most troublesome complication after pancreatoduodenectomy. The approach to management of the pancreatic remnant via ... -
Parent-Infant Sleep as Co-Occupation: A Meta-Ethnography of Parent Experiences and Perspectives
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Sleep is a key component of health and wellbeing for both adults and infants and has implications for daytime functioning and quality of life. Infants' sleep patterns in the first two years involve unpredictable, short ... -
Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
(2013)Trichinella spiralis is a highly destructive parasitic nematode that invades and destroys intestinal epithelial cells, injures many different tissues during its migratory phase, and occupies and transforms myotubes during ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Partners in Learning: An Investigation into a Service-Learning Module for Community Partners and Occupational Therapy Students
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2018)Service-learning is a pedagogical approach to learning which aims to link academic coursework to real word situations through the provision of service (Eyler & Giles, 1999). The body of literature concerning service-learning ... -
Patent nasopalatine ducts: Evidence to support persistence of the vomeronasal system?
(2018)The vomeronasal system is comprised of the nasopalatine duct and the vomeronasal organ. While this system functions in chemodetection in mammals, its presence and function in adult humans remains to be clearly elucidated. ... -
The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs.
(2017)Background: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological condition that requires coordinated, multidisciplinary clinical management. ALS is prone to misdiagnosis as its signs and symptoms may be ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.
(2013)BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune ... -
Pathways to Child Hospitalization
(Eastern Health Board. Dublin, 1988) -
Patient and family participation in healthcare design and delivery in a psychiatry and a type 2 diabetes service
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2019)Background: There is no consensus on the best way to include patients and family in healthcare design and delivery. This PhD aimed to develop, implement and test the feasibility of an intervention to encourage patient and ...