Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha.
Citation:
Smith, KJ, Norris, S, O'Dwyer, AM & O'Mara, SM., Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha., Neuropsychiatric Disease and Treatment, 2010, 1 18Download Item:
Smith et al Neuropsych Dis Treat 2010.pdf (Published (publisher's copy) - Peer Reviewed) 899.7Kb
Abstract:
Interferon-?, currently used for the treatment of hepatitis C, is associated with
a substantially elevated risk of depression. However, not everyone who takes this drug becomes
depressed, so it is important to understand what particular factors may make some individuals
more `at risk? of developing depression than others. Currently there is no consensus as to why
interferon-induced depression occurs and the range of putative risk factors is wide and diverse.
The identification of risk factors prior to treatment may allow identification of patients who will
become depressed on interferon, allowing the possibility of improved treatment support and
rates of treatment adherence. Here, we consolidate and review the literature on risk factors, and
we discuss the potential confounds within the research examined in order to better isolate the
risk factors that may be important in the development of depression in these patients and which
might help predict patients likely to become depressed on treatment. We suggest that interactions
between psychobehavioral, genetic, and biological risk factors are of particular importance in
the occurrence of depression in patients with hepatitis C taking interferon-?.
Sponsor
Grant Number
Health Research Board (HRB)
Author's Homepage:
http://people.tcd.ie/smomarahttp://people.tcd.ie/ofarrecl
Description:
PUBLISHED
Author: O'MARA, SHANE; O'FARRELLY, CLIONA
Type of material:
Journal ArticleCollections:
Series/Report no:
Neuropsychiatric Disease and TreatmentAvailability:
Full text availableKeywords:
Psychiatry, depression, Interferon-?, hepatitis CSubject (TCD):
Immunology, Inflammation & Infection , NeuroscienceLicences: