Browsing Psychiatry by Author "MC LOUGHLIN, DECLAN"
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Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
MC LOUGHLIN, DECLAN (2010)Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is a nuclear protein and the ... -
Electroconvulsive therapy, capacity and the law in Ireland.
DUNNE, ROSS; MC LOUGHLIN, DECLAN (Irish Institute of Psychological Medicine, 2009)The Mental Health Act (MHA) 2001 has major implications for treating patients with electroconvulsive therapy (ECT), especially as those referred for treatment are among the most severely ill and often lose capacity. Under ... -
Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease
MC LOUGHLIN, DECLAN (2010)X11? is a neuronal-specific adaptor protein that binds to the amyloid-? protein precursor (A?PP). Overexpression of X11? reduces A? production but whether X11? also protects against A?-related memory dysfunction is not ... -
Regional Variation in Electroconvulsive Therapy Use
MC LOUGHLIN, DECLAN; DUNNE, ROSS (2011)Although electroconvulsive therapy (ECT) is the most powerful treatment for depression, substantial variability in use has been described in Ireland. The Mental Health Commission collects usage data from approved centres ... -
Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply.
MC LOUGHLIN, DECLAN; AGYAPONG, VINCENT ISRAEL OPOKU (2013)Background. In recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory ... -
An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter.
MC LOUGHLIN, DECLAN (2010)X11? is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding (PTB) domain to inhibit production of A? peptide that is deposited in Alzheimer's ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
MC LOUGHLIN, DECLAN (2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ...