Browsing Psychiatry by Author "DONOHOE, GARY (JAMES)"
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Common variants at 12q14 and 12q24 are associated with hippocampal volume.
DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER (2012)Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer?s disease and vascular risk factors. Our genome-wide association study of dementia- free persons (n=9,232) identified 46 ... -
Genome-wide association study identifies five new schizophrenia loci.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL; DONOHOE, GARY (JAMES) (2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ... -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
Mental state decoding versus mental state reasoning as a mediator between cognitive and social function in psychosis
CORVIN, AIDEN PETER; DONOHOE, GARY (JAMES); GILL, MICHAEL; McGlade, Nicola; Behan, Caragh; Hayden, Judy; O'Donoghue, Therese; Peel, Rosie; Haq, Farhan; O'Callaghan, Eadbhard (2008)Theory of mind deficits in schizophrenia have been parsed into mental state reasoning and mental state decoding components. We report that mental state decoding as measured by the `Eyes task? better predicted social ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
MORRIS, DEREK; HARGREAVES, APRIL; CORVIN, AIDEN PETER; GILL, MICHAEL; ROBERTSON, DEIRDRE; DONOHOE, GARY (JAMES) (2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
CORVIN, AIDEN PETER; ROSE, EMMA; DONOHOE, GARY (JAMES); FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ...