Browsing Psychiatry by Author "BOLSHAKOVA, NADIA"

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  • Application of simulated annealing to the biclustering of gene expression data 

    BOLSHAKOVA, NADIA; CUNNINGHAM, PADRAIG (2006)
    In a gene expression data matrix, a bicluster is a submatrix of genes and conditions that exhibits a high correlation of expression activity across both rows and columns. The problem of locating the most significant ...

  • Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders 

    MERIKANGAS, ALISON; GALLAGHER, LOUISE; BOLSHAKOVA, NADIA (2014)
    Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus ...

  • A genomewide scan for common alleles affecting risk for autism. 

    ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO; HERON, ELIZABETH; MCGRATH, JANE; TANSEY, KATHERINE; BRENNAN, SEAN; MERIKANGAS, ALISON; MERIKANGAS, ALISON KATHLEEN (2010)
    Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ...