Browsing Psychiatry by Title
Now showing items 1-20 of 159
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A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
(2016)Background: Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately �190 million and �63 million, respectively, ... -
Abnormal functional connectivity in autism spectrum disorder is associated with disrupted white matter microstructural organisation
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Amyloid ? peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
(Elsevier, 2009)We measured concentrations of A? peptides 1?42 and 1?40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available ... -
An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
(Nature Publishing Group, 2008)The recent completion of the International HapMap Project has rapidly advanced our understanding of linkage disequilibrium (LD) in the human genome. Today, tagging SNPs (tSNPs) can be quickly and easily selected and ... -
The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism
(2014)Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires ... -
Autism spectrum disorder genomics: The progress and potential of genomic technologies
(2020)Genomic technologies have accelerated research progress in autism spectrum disorder (ASD) genomics and promises to further transform our understanding of the genetic basis of this neurodevelopmental disorder. Here we review ... -
Autistic Tendencies: The Consequences for Our Culture
(2006)Professor Michael Fitzgeraldtalks withJoe Griffinabout the powerful impact, both positive and negative, of autistic thinking in diverse walks of life. -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
(2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
Characterising schizophrenia candidate susceptibility genes using intermediate phenotypes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This thesis describes the use of intermediate phenotypes as a method for understanding, at a behavioural level, the functional significance of candidate susceptibility genes for schizophrenia. The historical context for ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ... -
Clinical and Genetic Rett Syndrome Variants are Defined by Stable Electrophysiological Profiles
(2018)Background: Rett Syndrome (RTT) is a complex neuro developmental disorder, frequently associated with epilepsy. Despite increasing recognition of the clinical heterogeneity of RTT and its variants (e.g Classical, Hanefeld ... -
Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q
(Elsevier, 2005)Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the ... -
Comment on "Nuclear genomic sequences reveal that polar bears are an old and distinct bear lineage".
(2013)Based on nuclear and mitochondrial DNA, Hailer et al. (Reports, 20 April 2012, p. 344) suggested early divergence of polar bears from a common ancestor with brown bears and subsequent introgression. Our population genetic ... -
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
(2012)Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer?s disease and vascular risk factors. Our genome-wide association study of dementia- free persons (n=9,232) identified 46 ...