Browsing Psychiatry by Title
Now showing items 212-231 of 434
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A genomewide scan for common alleles affecting risk for autism.
(2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
A genomewide scan for common alleles affecting risk for autism.
(Oxford University Press, 2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
(2018)Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and ... -
Geonome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
(2011)Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies ... -
Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.
(2019)Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially ... -
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
(Nature, 2010)We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association ... -
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
(2017)The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ... -
He said, she said: Autism spectrum diagnosis and gender differentially affect relationships between executive functions and social communication
(2019)Autism spectrum disorder is characterized by difficulties with social communication, with a preponderance in males. Evidence supports a relationship between metacognitive executive functions (e.g. planning, ... -
Hearing the Unheard: An Interdisciplinary, Mixed Methodology Study of Women's Experiences of Hearing Voices (Auditory Verbal Hallucinations).
(2015)This paper explores the experiences of women who "hear voices" (auditory verbal hallucinations). We begin by examining historical understandings of women hearing voices, showing these have been driven by androcentric ... -
High dose right unilateral versus moderate dose bilateral ECT for major depression : time to re-orientation, physical functioning, quality of life and attitudes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objective of this study was to compare the effects of 1.5 x seizure threshold (ST) bitemporal ECT with high dose (6 x ST) right unilateral (RUL) ECT with respect to immediate recovery from treatment, change in physical ... -
The hippocampus, amygdala and their principal output tracts in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Major depressive disorder is a common, debilitating illness. Despite its high prevalence rate and global disease burden, the biological mechanisms underlying this disorder remain largely unknown. Evidence points towards ... -
Home environment: association with hyperactivity/impulsivity in children with ADHD and their non-ADHD siblings.
(2013)We wished to ascertain if there is an association between symptoms of attention-deficit/hyperactivity disorder (ADHD) and home environment in children with ADHD and non-ADHD siblings, controlling for other environmental ... -
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
(2012)There is evidence that excessive stress exposure of the brain, mediated through the neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain structure and function: the glucocorticoid cascade ... -
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
(2016)The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still ...