Browsing Psychiatry by Title
Now showing items 202-221 of 434
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Genome-wide association study identifies five new schizophrenia loci.
(2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
(2009)We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
(2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
(Nature Publishing Group, 2009-11-15)Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
(2009)Ulcerative colitis (UC) is a common form of inflammatory bowel disease with a complex aetiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome- wide association scan for UC in 2361 cases ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
(2015)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
A genome-wide linkage and association scan reveals novel loci for autism.
(Nature, 2009)Although autism is a highly heritable neurodevelopmental disorder, attempts to identify specific susceptibility genes have thus far met with limited success 1. Genome-wide association studies (GWAS) using half a million ... -
Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression
(2011)Background: Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to suicidal attempts to completed suicide. In this study we identify genes contributing to suicidal behaviour in the depression ... -
A genomewide scan for common alleles affecting risk for autism.
(2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
A genomewide scan for common alleles affecting risk for autism.
(Oxford University Press, 2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
(2018)Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and ... -
Geonome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
(2011)Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies ... -
Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence.
(2019)Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially ... -
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
(Nature, 2010)We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association ... -
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
(2017)The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ...