Haematology: Recent submissions
Now showing items 1-5 of 36
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A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma
(2022)Aims: We have recently described a novel guanidinium-based compound, VP79s, which induces cytotoxicity in various cancer cell lines. Here, we aim to investigate the activity of VP79s and associated mechanisms of action in ... -
Epidemiology of chronic lymphocytic leukaemia in an Irish subpopulation with total case ascertainment: an additional tool for health economic planning
(2021)Chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) is the commonest B-cell malignancy affecting Caucasians, with a variable national incidence depending on the ethnic composition and age profile of ... -
The Impact of Advanced Patient Age on Mortality after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma: A Retrospective Study by the European Society for Blood and Marrow Transplantation Lymphoma Working Party
(2019)More than 60% of patients with non-Hodgkin lymphoma (NHL) are age>60 years at presentation. The purpose of thisstudy was to compare the potential risks and benefits of allogeneic hematopoietic cell transplantation (alloHCT) ... -
Defining the mechanisms through which von willebrand factor sialic acid expression regulates in vivo clearance
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)Von Willebrand Factor (VWF) is a complex plasma sialoglycoprotein which plays a key role in maintaining normal haemostasis. While the biosynthesis, structure, and functions of VWF are well characterised, the molecular ... -
Investigating the Role of Von Willebrand Factor in Regulating Macrophage Biology and Innate Immunity
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary haemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have suggested that VWF may ...