Browsing Haematology by Title
Now showing items 1-20 of 36
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ADAMTS13 substrate recognition of von Willebrand factor A2 domain.
(2006)ADAMTS13 controls the multimeric size of circulating von Willebrand factor (VWF) by cleaving the Tyr1605?Met1606 bond in theA2 domain. To examine substrate recognition, we expressed in bacteria and purified three A2 ... -
An investigation into the potential use of Beta-Galactoside binding protein as a novel anti-leukaemic agent
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)Chronic myelogenous leukaemia (CML) is characterised at the molecular level by a (9;22) translocation which places the abl proto-oncogene under the control of the breakpoint cluster region (bcr) gene promoter generating a ... -
Cellular and molecular mechanisms associated with sensitivity to DNA damaging agents in various human genetic disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2005)The integrity of the genome is important to cellular and organism homeostasis. It is under constant threat due to intrinsic and extrinsic factors which contribute to a variety of genetic alterations and so genomic integrity ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
Defining the mechanisms through which von willebrand factor sialic acid expression regulates in vivo clearance
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)Von Willebrand Factor (VWF) is a complex plasma sialoglycoprotein which plays a key role in maintaining normal haemostasis. While the biosynthesis, structure, and functions of VWF are well characterised, the molecular ... -
Defining the roles of von Willebrand Factor and Factor V111 glycosylation in regulating lectin interaction and modulating in vivo clearance
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2015)von Willebrand Factor (VWF) is a large multimeric sialoglycoprotein which mediates critical roles in normal haemostasis. VWF tethers platelets at sites of vascular injury and also serves as a chaperone for coagulation ... -
Detection of minimal residual disease and WT1 overexpression in childhood acute leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)Minimal residual disease (MRD), the post-treatment presence of a small submicroscopic amount of leukaemic cells in the bone marrow or other sites undetectable by conventional methods, has been recently shown to be one of ... -
Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
(2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Drug-induced veno-occlusive disease of the liver : unravelling the role of the inflammatory and coagulation pathways
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2008)The thiopurines thioguanine (6TG) and mercaptopurine (6MP), along with Mylotarg (an antibody targeted agent), are used in the treatment of acute leukaemias. These drugs are more commonly associated with the development of ... -
Epidemiology of chronic lymphocytic leukaemia in an Irish subpopulation with total case ascertainment: an additional tool for health economic planning
(2021)Chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) is the commonest B-cell malignancy affecting Caucasians, with a variable national incidence depending on the ethnic composition and age profile of ... -
Genetic analysis of the human prohibitin gene (PHB) in breast and other cancers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Prohibitin, an evolutionarily conserved gene situated on chromosome 17q21, was originally identified as a gene with antiproliferative properties. Studies of a Japanese population have shown prohibitin to be somatically ... -
The Impact of Advanced Patient Age on Mortality after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma: A Retrospective Study by the European Society for Blood and Marrow Transplantation Lymphoma Working Party
(2019)More than 60% of patients with non-Hodgkin lymphoma (NHL) are age>60 years at presentation. The purpose of thisstudy was to compare the potential risks and benefits of allogeneic hematopoietic cell transplantation (alloHCT) ... -
Incidence of Second Primary Malignancies after Autologous Transplantation for Multiple Myeloma in the Era of Novel Agents
(2018)The advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPMs). We examined the SPM rate in MM patients who were enrolled in the prospective ... -
Investigating the Role of Von Willebrand Factor in Regulating Macrophage Biology and Innate Immunity
(Trinity College Dublin. School of Medicine. Discipline of Haematology, 2019)The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary haemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have suggested that VWF may ... -
Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Isolation and characterisation of a monocyte protein C receptor : implications for novel therapeutic strategies in sepsis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2003)The protein C (PC) pathway provides a unique interface between the processes of coagulation, inflammation and fibrinolysis. Used as an adjunct to standard treatment, PC/activated PC to date, has been shown to be the only ... -
Melphalan 140 mg/m2or 200 mg/m2for autologous transplantation in myeloma: Results from the collaboration to collect autologous transplant outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT chronic malignancies working party
(2018)Melphalan at a dose of 200 mg/m2 is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m2 is often used in clinical practice in patients perceived ... -
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1.
(2013)Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously ... -
The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells
(2013)Although recent decades have seen an improved cure rate for newly diagnosed paediatric acute lymphoplastic leukemia (ALL), the treatment options for adult ALL, T-cell ALL (T-ALL) and relapsed disease remain poor. We have ...