Browsing Pharmacology & Therapeutics by Title
Now showing items 70-84 of 84
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Regulation of expression of transcription factors nuclear factor-kappa B and early growth response-1 by Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The Gram-negative bacterium Helicobacter pylori colonizes the human gastric epithelium and is a causative agent of peptic ulcer disease and gastric adenocarcinoma. Although H. pylori colonization is associated with gastric ... -
Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression.
(2009)An animal model of depression combining genetic vulnerability and early-life stress (ELS) was prepared by submitting the Flinders Sensitive Line (FSL) rats to a standard paradigm of maternal separation. We analysed hippocampal ... -
Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ... -
Role of Protein Phosphatase 2A inhibition in modulation of VE-cadherin and Claudin-5 in human brain microvascular endothelial cells and the potential reversal by small molecule activators of PP2A (SMAPs)
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2021)Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase which plays a key role in modulating signalling, metabolism and cell growth, and is implicated in various pathologies. There is conflicting evidence regarding ... -
Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity
(2014)Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of ... -
Stress and long-term potentiation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ... -
Structural remodelling of the vascular wall in relation to ageing and arterial stiffening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)Structural remodelling of the vascular wall has been investigated in this study in terms of ageing and the process of vascular stiffening. While common structural adaptations are often presumed for ageing and vascular ... -
Supporting the improvement and management of prescribing for urinary tract infections (SIMPle): protocol for a cluster randomized trial
(2013)Background The overuse of antimicrobials is recognized as the main selective pressure driving the emergence and spread of antimicrobial resistance in human bacterial pathogens. Urinary tract infections (UTIs) are among ... -
Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus.
(2013)Both electrically induced synaptic long-term potentiation (LTP) and long-term depression have been extensively studied as models of the cellular basis of learning and memory mechanisms. Recently, considerable interest has ... -
Synaptic plasticity in animal models of stress : serotonergic mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ... -
The influence of antiviral therapy and HIV / HCV proteins on matrix metalloproteinase and cytokine production : an in vitro and in vivo study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The effect of antiviral therapy on MMP/TIMP expression in THP-1 and LX-2 cells and in HIV/HCV co-infected patients: MMP-9 activity was measured by gelatin zymography, MMP-9 mRNA expression by real-time RT PCR, and MMP-9, ... -
The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ... -
β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ...