Browsing Pharmacology & Therapeutics by Title
Now showing items 14-33 of 84
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A cohort study of metformin exposure and survival in patients with stage I-III colorectal cancer
(2013)Background: Preclinical evidence suggests a beneficial effect of metformin in colorectal cancer. This study aimed to investigate associations between metformin exposure and colorectal cancer–specific survival using ... -
Comorbidity and Type 2 Diabetes : prevalence, type and impact on cost and health-related behaviours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)Comorbidity is the co-existence of one or more additional conditions in patients with a specified medical condition. It is highly prevalent in patients with diabetes and may be related (concordant) or unrelated (discordant) ... -
Comparing primary prevention with secondary prevention to explain decreasing coronary heart disease death rates in Ireland 1985 - 2000
(2007)BACKGROUND: To investigate whether primary prevention might be more favourable than secondary prevention (risk factor reduction in patients with coronary heart disease(CHD)). METHODS: The cell-based IMPACT CHD mortality ... -
A competing risks prescription refill model of compliance and persistence.
(2010)Objectives There is evidence to suggest that noncompliant and nonpersistent behaviors have differing risk factors, clinical consequences, and responses to intervention. This has led to calls for these behaviors to be defined ... -
Cost Effectiveness of PCSK9 Inhibitors for the Secondary Prevention of Cardiovascular Disease in Ireland: Considerations given to Population Heterogeneity
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The aim of this thesis was to evaluate the cost-effectiveness of PCSK9 inhibitors (alirocumab and evolocumab for the secondary prevention of CVD (cardiovascular disease) in Ireland. Also, to identify the subgroups of this ... -
Cost Effectiveness of Treatment Strategies for Skin Cancer in the Irish Healthcare Setting
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2020)The incidence of both non-melanoma skin cancer (NMSC) and melanoma skin cancer are increasing in Ireland and are associated with significant healthcare costs. Cost-effectiveness analysis (CEA) can assist in resource ... -
Cost-effectiveness of anti-tumour necrosis factor drugs for the treatment of rheumatoid arthritis in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)Rheumatoid Arthritis (RA) is the most common form of inflammatory arthritis. It is a chronic condition that places a substantial burden on patients and their carers, imposing a negative effect on quality of life (QOL), ... -
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
(Oxford University Press, 2008)Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the ... -
DIFFERENTIAL INTERACTIONS OF ANTIRETROVIRAL AGENTS WITH LXR, ER AND GR NUCLEAR RECEPTORS - POTENTIAL CONTRIBUTING FACTORS OF ADVERSE EVENTS
(2014)BACKGROUND AND PURPOSE: Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions due to altered drug metabolism and disposition. The closely ... -
Elimination half-life may explain the relative efficacy of boceprevir and telaprevir in the treatment of hepatitis c virus genotype 1
(2013)Background. The licensing of direct-acting antivirals heralds a new era in the treatment of hepatitis C virus (HCV) genotype 1. We undertook a mixed treatment comparison to examine the relative efficacy among current ... -
Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ... -
Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo.
(2013)Abstract BACKGROUND: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer's disease (AD)-associated amyloid β-protein (Aβ). ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi)
(2015)OBJECTIVE: Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
(2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Health technology assessment in the Irish healthcare setting : application to oral anticoagulants
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The objective of this thesis was to examine the application of economic evaluation within the Irish healthcare setting. In so doing, the author sought to develop skills in indirect comparison, economic modelling, value of ...