Browsing Pharmacology & Therapeutics by Title
Now showing items 21-40 of 84
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Cost-effectiveness of anti-tumour necrosis factor drugs for the treatment of rheumatoid arthritis in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)Rheumatoid Arthritis (RA) is the most common form of inflammatory arthritis. It is a chronic condition that places a substantial burden on patients and their carers, imposing a negative effect on quality of life (QOL), ... -
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
(Oxford University Press, 2008)Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the ... -
DIFFERENTIAL INTERACTIONS OF ANTIRETROVIRAL AGENTS WITH LXR, ER AND GR NUCLEAR RECEPTORS - POTENTIAL CONTRIBUTING FACTORS OF ADVERSE EVENTS
(2014)BACKGROUND AND PURPOSE: Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions due to altered drug metabolism and disposition. The closely ... -
Elimination half-life may explain the relative efficacy of boceprevir and telaprevir in the treatment of hepatitis c virus genotype 1
(2013)Background. The licensing of direct-acting antivirals heralds a new era in the treatment of hepatitis C virus (HCV) genotype 1. We undertook a mixed treatment comparison to examine the relative efficacy among current ... -
Endogenous acetylcholine modulates synaptic plasticity in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Long-term potentiation (LTP) provides a model for the synaptic mechanisms underlying learning and memory. Acetylcholine (ACh) is an important excitatory transmitter in the hippocampus, and cholinergic activity is essential ... -
Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo.
(2013)Abstract BACKGROUND: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer's disease (AD)-associated amyloid β-protein (Aβ). ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi)
(2015)OBJECTIVE: Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
(2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Health technology assessment in the Irish healthcare setting : application to oral anticoagulants
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The objective of this thesis was to examine the application of economic evaluation within the Irish healthcare setting. In so doing, the author sought to develop skills in indirect comparison, economic modelling, value of ... -
Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting.
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2022)The aim of this research was to undertake health technology assessments of CD19 CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel. A bespoke cost-utility model was developed to examine the cost effectiveness ... -
Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study.
(2015)ACKGROUND: Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a ... -
Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2017)Abstract: Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors Kenneth J. O?Riordan Department of Pharmacology and Therapeutics School of Medicine, University ... -
Identifying early indicators of Emotional and Behavioural Difficulties in Irish children and testing the feasibility of an online parenting intervention for improving child mental health
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2019)Background: Emotional and behavioural difficulties (EBDs) are the most common reason for referral of children and adolescents to mental health services. It is important, therefore, to assess the overall prevalence of EBD ... -
The innate immunomodulatory effects of Aquamin in the context of the metabolic syndrome
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2023)Metabolic disease is a combination of conditions that manifest together, elevating the risk for cardiovascular disease, type 2 diabetes and stroke. Inflammation is a major contributor in the pathophysiology of metabolic ... -
Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.
(2011)A role for PrP in the toxic effect of oligomeric forms of A?, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ... -
Left ventricular diastolic function in early hypertension
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)This thesis presents the development of clinical applications of the relatively new ultrasound modality, TDI in conjunction with the earlier more established modalities of echocardiography. The contents of this thesis ...