Neural mechanisms for response selection: comparing selection of items and responses from working memory.
Item Type:Journal Article
Citation:Hester, R., D?Esposito, M., Cole, M. W. & Garavan, H. `Neural mechanisms for response selection: comparing selection of items and responses from working memory? in NeuroImage, 34, 1, (2007), pp 446 - 454
Hester NI07.pdf (published (publisher copy) peer-reviewed) 445.6Kb
Recent functional imaging studies of working memory (WM) have suggested a relationship between the requirement for response selection and activity in dorsolateral prefrontal (DLPFC) and parietal regions. Although a number of WM operations are likely to occur during response selection, the current study was particularly interested in the contribution of this neural network to WM-based response selection when compared to the selection of an item from a list being maintained in memory, during a verbal learning task. The design manipulated stimulus?response mappings so that selecting an item from memory was not always accompanied with selecting a motor response. Functional activation during selection supported previous findings of fronto-parietal involvement, although in contrast to previous findings left, rather than right, DLPFC activity was significantly more active for selecting a memory-guided motor response, when compared to selecting an item currently maintained in memory or executing a memory-guided response. Our results contribute to the debate over the role of fronto-parietal activity during WM tasks, suggesting that this activity appears particularly related to response selection, potentially supporting the hypothesized role of prefrontal activity in biasing attention toward task-relevant material in more posterior regions.
Author: GARAVAN, HUGH PATRICK
Type of material:Journal Article
Availability:Full text available