Browsing Surgery by Title
Now showing items 158-176 of 176
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Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
(2014)The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Naïve T cells ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ... -
The immunomodulatory chemokine CCL28 in oesophageal disease progression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ... -
The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested ... -
To survive or to thrive: An investigation into fatigue and associated factors on surgical performance
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Background The issue of fatigue has been long-standing in the profession of surgery. Typically the term has been associated with performance decrement, and in particular, focus has been on mitigating fatigue to prevent ... -
The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation.
(2020)Background: Only 10-30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ... -
Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
(2011)Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic cells. However, the constituents ... -
Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment
(2018)Despite treatment of patients with metastatic colorectal cancer (mCRC) with bevacizumab plus chemotherapy, response rates are modest and there are no biomarkers available that will predict response. The aim of this study ... -
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic adenocarcinoma (PDAC) is a lethal malignancy with a poor survival rate. One main challenge regarding PDAC is resistance to chemotherapy and radiotherapy. Therefore, there is an urgent requirement to characterise ... -
An unusual presentation of Boerhaave Syndrome: a case report
(BioMed Central, 2009)We present a unique case of Boerhaave Syndrome that may highlight the spectrum of barotrauma from a Mallory-Weiss tear to full-thickness perforation. In this case, perforation only became evident following air insufflation ... -
The value of double balloon enteroscopy in diagnosing blue rubber bleb naevus syndrome: a case report.
(BioMed Central, 2010)Blue rubber bleb naevus syndrome is a rare vascular disorder associated with multiple gastrointestinal haemangiomas that have the potential for life-threatening haemorrhage. These may be difficult to diagnose, and have ... -
Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
(2001)Tumour progression is regulated by the balance of proliferation and apoptosis in the tumour cell population. To date, the role of vascular endothelial growth factor (VEGF) in tumour growth has been attributed to the induction ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
(2015)Background: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ... -
Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.
(2019)Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity ... -
Visceral adiposity and oesophageal adenocarcinoma : exploring the role of the insulin like-growth factor axis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2012)In the modem era there is a consistent reported trend of markedly improved operative and oncologic outcomes from high-volume oesophageal programmes within academic medical centres. The current benchmark survival rate in ... -
Visceral adiposity, insulin resistance and cancer risk
(2011)Background: There is a well established link between obesity and cancer. Emerging research is characterising this relationship further and delineating the specific role of excess visceral adiposity, as opposed to simple ... -
When to Perform a Pancreatoduodenectomy in the Absence of Positive Histology? A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS)
(2014)Pancreatoduodenectomy (PD) provides the best chance for cure in the treatment of patients with localized pancreatic head cancer. In patients with a suspected, clinically resectable pancreatic head malignancy, the need for ...
