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Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers.
(2010)
Hippocampal mossy fibers project preferentially to the proximal-most lamina of the suprapyramidal region of CA3, the stratum lucidum, and proximal-most parts of the infrapyrmidal region of CA3c. Molecular mechanisms that ...
Biasing switching outcomes in the Escherichia coli fim site-specific recombination system through DNA supercoiling and nucleoid-associated proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)
Type 1 fimbriae are typically expressed in nutrient poor environments and facilitate colonization through attachment when the bacterium can no longer support a motile lifestyle that demands a high metabolic flux. They play ...
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
(2010)
Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular ...
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
(BioMed Central, 2010)
Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning ...
Downstream Effects of Haemoglobinase Inhibition in Plasmodium falciparum-Infected Erythrocytes
(2010)
Blood-stage malarial parasites (Plasmodium falciparum) digest large quantities of host haemoglobin during their asexual development in erythrocytes. The haemoglobin digestion pathway, involving a succession of cleavages ...
Chromosomal G + C content evolution in yeasts: systematic interspecies differences, and GC-poor troughs at centromeres.
(2010)
The G + C content at synonymous codon positions (GC3s) in genes varies along chromosomes in most eukaryotes. In Saccharomyces cerevisiae, regions of high GC3s are correlated with recombination hot spots, probably due to ...
pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis.
(2010)
Plasmid pBaSysBioII was constructed for high-throughput analysis of gene expression in Bacillus subtilis. It is an integrative plasmid with a ligation-independent cloning (LIC) site, allowing the generation of transcriptional ...
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen
(2010)
The ligand binding domain of the fibrinogen binding protein from Staphylococcus lugdunensis (Fbl) shares 60% sequence identity with clumping factor A (ClfA) of Staphylococcus aureus. Recombinant Fbl corresponding to the ...
Defining the role of the AP2/ERF transcription factors Rap2.4 and Rap2.4b in stress responses in the model plant Arabidopsis thaliana
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2010)
This study characterises the molecular properties and the function of two Arahidopsis
AP2/ERF transcription factors, Rap2.4 and Rap2.4b. The two genes belong to the DREB subgroup, members of which have been demonstrated ...
Ohnologs in the human genome are dosage balanced and frequently associated with disease
(2010)
About 30% of protein-coding genes in the human genome are
related through two whole genome duplication (WGD) events.
Although WGD is often credited with great evolutionary importance,
the processes governing the retention ...