Browsing School of Genetics & Microbiology by Subject "Tight junction"

Now showing items 1-5 of 5

    • The blood-brain barrier in neuropsychiatric disorders 

      GREENE, CHRIS (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
      Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ...

    • Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier 

      Campbell, Matthew (2021)
      Claudin-5 is the dominant tight junction protein in brain endothelial cells and exclusively limits the paracellular permeability of molecules larger than 400Da across the blood–brain barrier (BBB). Its pathological impairment ...

    • Claudin-5: Gatekeeper of neurological function 

      Campbell, Matthew; Greene, Chris (2019)
      Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates ...

    • Tight Junctions of the Neurovascular Unit 

      Campbell, Matthew; Hudson, Natalie (2021)
      The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the ...

    • Tight junctions of the outer blood retina barrier 

      Campbell, Matthew; Hudson, Natalie (2020)
      The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction ...