Browsing School of Genetics & Microbiology by Subject "Retinal degeneration"
Now showing items 1-4 of 4
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AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice
(2022)Recombinant adeno-associated virus (AAV) vectors are one of the main gene delivery vehicles used in retinal gene therapy ap proaches; however, there is a need to further improve the effi cacy, tropism, and safety of these ... -
Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration
(2022)The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a ... -
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
(2020)Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in axonal degeneration, ...