Browsing School of Genetics & Microbiology by Author "Martin, Seamus"
Now showing items 1-5 of 5
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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Mc Lysaght, Aoife; Bracken, Adrian; Martin, Seamus (2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
How to prepare and deliver a great talk
Martin, Seamus; Gemayel, Rita (2019)Giving a talk can be daunting, particularly for scientists at the very early stages of their careers. Standing in front of an audience and speaking for 20–30 minutes do is never easy, and even those who do it for a ... -
ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Martin, Seamus (eLife Sciences Publications, 2018)The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves ... -
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Walsh, Patrick; Lavelle, Edward; Munoz-Wolf, Natalia; Martin, Seamus (2022)Interleukin-1 (IL-1) family cytokines are key barrier cytokines that are typically expressed as inactive, or partially active, precursors that require proteolysis within their amino termini for activation. IL-37 is an ... -
To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps
Martin, Seamus (Springer Nature, 2019)Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics andphysiological functions of NETs have been uncovered. Nowadays, thefield continues to expand and novel ...