Browsing School of Genetics & Microbiology by Author "MARTIN, SEAMUS JOSEPH"
Now showing items 1-3 of 3
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Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
CREAGH, EMMA; MARTIN, SEAMUS JOSEPH (2001)Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of the IAP family of apoptosis inhibitory proteins. Smac has been shown to exit mitochondria and ... -
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man
MARTIN, SEAMUS JOSEPH; CREAGH, EMMA (The American Society for Biochemistry and Molecular Biology, 2004)The caspase family of cysteine proteases plays a conserved role in the coordinate demolition of cellular structures during programmed cell death from nematodes to man. Because cells undergoing programmed cell death in ... -
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
LAVELLE, EDWARD; MARTIN, SEAMUS JOSEPH; LUTHI, ALEXANDER; SHERIDAN, CLARE (2009)Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to ...