Browsing School of Genetics & Microbiology by Title
Now showing items 593-612 of 870
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P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER
(2001)BACKGROUND/AIMS-NON-MELANOMA SKIN CANCERS FREQUENTLY HARBOUR MULTIPLE HUMAN PAPILLOMAVIRUS (HPV) TYPES. A RECENT REPORT SUGGESTS THAT ALPOLYMORPHISM OF THE P53 TUMOUR SUPPRESSOR GENE THAT RESULTS IN THE SUBSTITUTION OF A ... -
Packing a punch: Understanding how flavours are produced in lager fermentations
(2021)Beer is one of the most popular beverages in the world and it has an irreplaceable place in culture. Although invented later than ale, lager beers dominate the current market. Many factors relating to the appearance (colour, ... -
Paging through history: Parchment as a reservoir of ancient DNA for next generation sequencing
(2015)Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of ... -
Panel-Based population next-generation sequencing for inherited retinal degenerations
(2016)Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated in these ... -
Parallel evolution of the make?accumulate?consume strategy in Saccharomyces and Dekkera yeasts
(Nature, 2011)Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make?accumulate?consume' ... -
The parallel lives of Joseph Allen Galbraith (1819-90) and Samuel Haughton (1821-97): religion, friendship, scholarship and politics in Victorian Ireland.
(Royal Irish Academy, 2012)Joseph Allen Galbraith and Samuel Haughton were both Junior Fellows at Trinity College Dublin, who in the 1840s became popular lecturers of mathematics-based subjects as well as successful textbook authors. In the 1880s ... -
Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
(2014)Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via ... -
Pathogenomic analysis of the common bovine Staphylococcus aureus clone (ET3): emergence of a virulent subtype with potential risk to public health
(University of Chicago Press, 2008)A common clone (ET3) of Staphylococcus aureus is responsible for a large proportion of cases of bovine mastitis and occasionally causes zoonotic infections of humans. In the present study, we report the identification of ... -
Patterns of gene expression during Arabidopsis flower development from the time of initiation to maturation
(2015)Background The formation of flowers is one of the main model systems to elucidate the molecular mechanisms that control developmental processes in plants. Although several studies have explored gene expression during ... -
Patterns of regulation of gene expression and genetic novelty in mammalian species
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Genetic novelty is the driving force behind evolution. Consequently, a large amount of genetic research is dedicated to determining the mechanisms behind, and the effects of, the creation of new genes. Where and when these ... -
pBaSysBioII: an integrative plasmid generating gfp transcriptional fusions for high-throughput analysis of gene expression in Bacillus subtilis.
(2010)Plasmid pBaSysBioII was constructed for high-throughput analysis of gene expression in Bacillus subtilis. It is an integrative plasmid with a ligation-independent cloning (LIC) site, allowing the generation of transcriptional ... -
Percy Kirwan - Long Jumper, Triple Jumper and Olympic Judge
(The Athletics Association of Ireland, 2013) -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
A perspective on mammalian caspases as positive and negative regulators of inflammation.
(2012)Members of the caspase family of cysteine proteases coordinate the morphological and biochemical events that typify apoptosis. However, neutralization of caspase activity in mammals fails to block death in response to ... -
Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA.
(2011)GcvB is one of the most highly conserved Hfq-associated small RNAs in Gram-negative bacteria and was previously reported to repress several ABC transporters for amino acids. To determine the full extent of GcvB-mediated ... -
PEST sequences in the malaria parasite Plasmodium falciparum: a genomic study
(BioMed Central, 2003)Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of the mosquito ... -
The phenotypic plasticity of duplicated genes in Saccharomyces cerevisiae and the origin of adaptations
(2017)Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of ...
