Browsing School of Genetics & Microbiology by Title
Now showing items 308-327 of 870
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The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin
(1993)The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the gamma 1 and gamma 2 components, respectively. ... -
A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
(2012)Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly ... -
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity
(2015)Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations ... -
Gene duplication in the coral genus Acropora
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Whole Genome Duplications (WGD) pose major evolutionary events, giving rise to increased gene diversity. They have often been associated with major changes e.g. mass extinctions. The coral genus Acropora is a reef-building ... -
Gene expression changes during retinal development and rod specification
(2015)Purpose: Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies ... -
Gene expression profiles during early differentiation of mouse embryonic stem cells
(2009)Background Understanding the mechanisms controlling stem cell differentiation is the key to future advances in tissue and organ regeneration. Embryonic stem (ES) cell differentiation can be triggered by embryoid body ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
Gene regulation and the Fis nucleoid-associated protein in Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)The Fis protein was found to influence the superhelical density of DNA and its ability to do this differed between Salmonella enterica serovar Typhimurium (S. typhimurium) and Escherichia coli (E. coli). Induction of the ... -
Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ... -
Gene therapy strategies for dominant heterogeneous disorders and the identification of a novel gene causing retinitis pigmentosa and sensorineural deafness
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The purpose of this Ph.D. thesis has been to contribute towards the generation of therapies for inherited disorders such as retinitis pigmentosa (RP) and osteogenesis imperfecta (OI). In chapter 2, a novel mitochondrial ... -
Genetic admixture analysis of domesticated cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic admixture analysis of bovine hybrid zones was carried out through implementation of a variety of statistical and analytical methods. Population genetic analysis of microsatellite variation in seven cattle breeds ... -
Genetic analyses of thalamocortical axon guidance and subpallial development
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Normal brain functioning in mammals depends on the establishment of specific, finely-organised neural networks connecting distant regions during development. In particular, sensory stimuli processing is supported by ... -
Genetic analysis of gentamicin resistance in methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals.
(American Society for MIcrobiology, 1988)Methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals have been classified into groups I, II, and III based on resistance to antimicrobial agents and plasmid profiles. Each ... -
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
(2011)African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more ... -
Genetic and Molecular Studies of Virulence Factors of Staphylococcus aureus
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023) -
Genetic diagnosis and treatment of inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ... -
Genetic diversity of Helicobactor pylori isolates through Microevolution in vivo
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)Chronic infection with H. pylori causes peptic ulcer disease and its presence is strongly linked with gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. One of the most interesting characteristics ...