Browsing School of Genetics & Microbiology by Title
Now showing items 180-199 of 873
-
Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ... -
Different patterns of gain and loss in genomic evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ... -
Differential apicobasal VEGF signaling at vascular blood-neural barriers
(2014)The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal ... -
The dipeptide repeat region of the fibrinogen-binding protein (clumping factor) is required for functional expression of the fibrinogen-binding domain on the Staphylococcus aureus cell surface.
(1997)Clumping factor of Staphylococcus aureus is a fibrinogen‐binding protein that is located on the bacterial cell surface. The protein has an unusual repeat domain (region R) comprising mainly the dipeptide aspartate and ... -
Discovery and engineering of antimicrobial peptides to combat food spoilage
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)This work sought to use a bioinformatics based approach to discover plant derived antimicrobial peptides which were structurally similar to human β-defensin 3 (HBD3) and which possessed effective antimicrobial activity ... -
Dissecting the functional link between transcription factor codes and axon guidance genes in Drosophila motor neurons
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)As axons navigate through the extracellular environment they are exposed to different guidance cues that will steer them when sensed by receptors and cell adhesion molecules [CAMS) present on their membranes. The intricate ... -
Distinct phenotypes and transcriptomes of tup1 and cyc8 mutants suggest novel roles for TUP1 and CYC8 in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2023)The Tup1-Cyc8 (Ssn6) co-repressor complex is a regulator of gene transcription in the yeast Saccharomyces cerevisiae. This project provides insights into the distinct roles of Tup1p and Cyc8p in gene repression, identifies ... -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12
(2006)Site-specific recombinases of the integrase family usually require cofactors to impart directionality in the recombination reactions that they catalyze. The FimB integrase inverts the Escherichia coli fim switch (fimS) in ... -
DNA supercoiling and transcription: a two-way street
(2019)Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because ... -
Downstream Effects of Haemoglobinase Inhibition in Plasmodium falciparum-Infected Erythrocytes
(2010)Blood-stage malarial parasites (Plasmodium falciparum) digest large quantities of host haemoglobin during their asexual development in erythrocytes. The haemoglobin digestion pathway, involving a succession of cleavages ... -
Drug Repurposing as a Strategy to Uncover Effective Antibacterial Compounds using Salmonella as a model
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Without doubt, antimicrobial resistance (AMR) is one of the most serious global challenge for public, animals and environmental health. Tackling this huge issue that is threatening modern medicine, is an urgent priority ... -
Dual Origins of Dairy Cattle Farming Evidence from a Comprehensive Survey of European Y-Chromosomal Variation
(PLoS, 2011)Background: Diversity patterns of livestock species are informative to the history of agriculture and indicate uniqueness of breeds as relevant for conservation. So far, most studies on cattle have focused on mitochondrial ... -
Duplicability of self-interacting human genes.
(2010)Background: There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model ...