Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 98
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The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus? dry powder inhaler
(2014)Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of ... -
Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling
(2013)The aim of this paper is to investigate the physicochemical properties of binary amorphous dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling. The sulfonamides selected were sulfathiazole ... -
Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil
(2016)Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO).Themajor component ... -
Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation
(2020)This study proposes lipid nanocapsules (LNCs)-based Trojan particles made by entrapping 59 ± 3 nm LNCs in carbohydrate-based microparticles via spray drying. This work focused on optimisation of maintenance of the nanocarrier ... -
CdTe quantum dots induce activation of human platelets: implications for particle hemocompatibility.
(2015)New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests ... -
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)Background: There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere?) represents the most active chemotherapeutic agent it only gives a modest survival ... -
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ... -
Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose
(2015)PURPOSE: To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
(2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation
(2016)In the present study, in vitro permeation experiments in a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine (RV) transdermal drug delivery system. ... -
A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
(2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ... -
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
(2018)Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task ... -
Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis.
(2013)Weighted gene coexpression network analysis (WGCNA) is a powerful 'guilt-by-association'-based method to extract coexpressed groups of genes from large heterogeneous messenger RNA expression data sets. We have utilized ... -
Crystallo-co-spray drying as a new approach to manufacturing of drug/excipient agglomerates: impact of processing on the properties of paracetamol and lactose mixtures.
(2020)The novel process of crystallo-co-spray drying of paracetamol and α-lactose monohydrate was investigated by varying the spray dryer inlet temperature and inlet feed solvent composition. A crystalline agglomerate was obtained ... -
Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction
(2019)We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T–P–V thermodynamic conditions in terms of density scaling concept. The studied material was found ...