Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Title
Now showing items 32-51 of 445
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Barriers and facilitators of medicines reconciliation at transitions of care in Ireland - a qualitative study
(2020)Background: Medication error at transitions of care is common. The implementation of medicines reconciliation processes to improve this issue has been recommended by many regulatory and safety organisations. The aim of ... -
Baseline study of Community Pharmacy Practice in Ireland - report
(Pharmaceutical Society of Ireland, 2011) -
Benzodiazepine usage in the North Eastern Health Board region of the Republic of Ireland
(2004)Introduction: Benzodiazepines are a large group of drugs used as hypnotics, anxiolytics, and tranquillisers, anti convulsants, pre-medication and for intravenous sedation. Extended use of benzodiazepines may lead to ... -
Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERalpha and ERbeta Activity
(2018)The two nuclear estrogen receptors (ERα and ERβ) mediate the biological effects of the estrogen hormones and ERα is an attractive therapeutic target for diseases including breast cancer and osteoporosis. Estrogens are known ... -
Bioactive Indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.
(2020)A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical ... -
Biocompatible copolymer formulations to treat glioblastoma multiforme.
(2021)The treatment for glioblastoma multiforme (GBM) has not changed for more than 20 years while the prognosis for the patients is still poor and most of them survive less than 1 year after diagnosis. The standard of care for ... -
Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems
(2013)Developing amorphous pharmaceuticals can be desirable due to advantageous biopharmaceutical properties. Low glass transition temperature (Tg) amorphous drugs can be protected from crystallisation by mixing with high Tg ... -
A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos
(2021)Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural platform for the enhanced targeting ... -
Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation
(2020)This study proposes lipid nanocapsules (LNCs)-based Trojan particles made by entrapping 59 ± 3 nm LNCs in carbohydrate-based microparticles via spray drying. This work focused on optimisation of maintenance of the nanocarrier ... -
Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury.
(2019)Hypoxic injury of cardiovascular system is one of the most frequent complications following ischaemia. Heart injury arises from increased degradation of contractile proteins, such as myosin light chains (MLCs) and troponin ... -
Carissa spinarum L.: A Case Study in Ethnobotany and Bioprospecting Research
(Intech Open, 2022)This study explores ethnobiological and bioprospecting research through the lens of Carissa spinarum L., using it as a case study to examine wider trends in such research. Hunn’s Phasing in Ethnobiology is used as a ... -
CdTe quantum dots induce activation of human platelets: implications for particle hemocompatibility.
(2015)New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests ...