Browsing Pharmacy and Pharmaceutical Sciences (Scholarly Publications) by Title
Now showing items 376-395 of 435
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Selective PKCalpha inhibition uncouples platelet angiogenesis promotion from collagen-induced aggregation
(2013)Platelets promote angiogenesis by releasing angiogenesis-regulating factors from their α-granules upon aggregation. This effect has both physiologic and pathologic significance as it may contribute to carcinogenesis. ... -
Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers
(2014)This work investigates a new type of polyelectrolyte complex nanocarrier composed of hyaluronic acid (HA) and protamine (PROT). Small (approximately 60 nm) and negatively charged nanoparticles (NPs) with a polydispersity ... -
Setting up a Cell Culture Laboratory
(Elsevier Academic Press, 2006) -
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog
(2003)The objective of this study was to compare two aspirin prodrugs, isosorbide diaspirinate (ISDA) and a nitroaspirin (ISMNA), with aspirin in terms of effects on dog platelet function after administration of a single oral ... -
Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2015)Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, ... -
Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt
(Wiley, 2011)The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, ... -
Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation
(2014)Pharmaceutical applications which require knowledge of the solubility of a crystalline compound in an amorphous matrix are abundant in the literature. Several methods that allow the determination of such data have been ... -
Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1
(2015)Strong evidence showed neurotoxic properties of beta amyloid (Aβ) and its pivotal role in the Alzheimer's disease (AD) pathogenesis. Beside, experimental data suggest that Aβ may have physiological roles considering that ... -
Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells
(2010)At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body. Here, we investigated how these proteinases affect drug ... -
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery
(2013)In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of ... -
Stress-Related Immune Markers in Depression: Implications for Treatment
(2016)Major depression is a serious psychiatric disorder; however, the precise biological basis of depression still remains elusive. A large body of evidence implicates a dysregulated endocrine and inflammatory response system ... -
Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders
(2017)The kynurenine pathway (KP), which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation of this tryptophan metabolising pathway ... -
Studies on Tinospora cordifolia monosugars and correlation analysis of uronic acids by spectrophotometry and GLC
(2014)Cold water-soluble (CWSP) and hot water soluble polysaccharides (HWSP) from Tinospora cordifolia stems were isolated and purified in 2.99% and 1.99% yield respectively. Complete hydrolysis followed by paper chromatography ...
