Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 36-55 of 61
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Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ... -
Polyamines and polyamine antagonists in cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Polyamines are ubiquitous components of all eukaryotic cells and are found in brain tissue. A number of studies have shown that changes in the levels of polyamines occur following cerebral ischaemia. However, whether ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
RBL-2H3 and primary mast cells and their use in screening novel anti-inflammatory compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Mast cells (MC) have been mainly studied as key effectors in allergic diseases and inflammatory conditions such hypersensitivity reactions, asthma, atopic dermatitis and multiple sclerosis. Following the crosslinkage of ... -
Solid-state characteristics of pre- and post-spray dried active pharmaceutical ingredients, salts and co-crystalline forms
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Salt or co-crystal formation is one of the methods of altering the physicochemical properties of an active pharmaceutical ingredient (API). The drug characteristic can also be changed upon processing. This thesis focused ... -
A study of glial associated changes in the complexity of primary cortical neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Neuroinflammation and disruptions in the integrity of neuronal circuitry are hallmarks of a range of CNS disorders. There is extensive evidence linking pro-inflammatory signalling and glial dysfunction with neuronal atrophy ... -
Synthesis, characterisation and drug release from a range of novel smart co-biodegrable delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)In recent years many biodegradable polymers have been investigated particularly for controlled delivery of drugs or proteins/peptides. The most commonly studied biodegradable polymers for controlled drug delivery are based ... -
Synthetic amorphous silica nanoparticles induce human endothelial cell inflammation and platelet aggregation : role of NF-kB and reactive nitrogen species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: The human population has been exposed to nanoparticles (particles with nano-dimensions) throughout all its evolutionary process; however, this exposure has been increased since the industrial ... -
The design, implementation, and evaluation of a medication safety programme in an acute Irish teaching hospital
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The research undertaken for this thesis aimed to address the current deficit which exists in relation to the status of medication safety in Irish hospitals and add to the limited body of published data available from any ... -
The design, synthesis and biological effects of novel steroid prodrugs for treatment of gastrointestinal diseases
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The aim of the work described in this thesis was to synthesize and test the biological effects of a novel type of prodrug to deliver steroids to the colon for the treatment of gastrointestinal diseases. Glucocorticoids are ... -
The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The purpose of the work undertaken within this project was to design and synthesis novel anti-cancer targeting compounds building upon previous work undertaken under the supervision of Dr. John J. Walsh in the School of ... -
The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The objective of this project was to design, synthesise and carry out preliminary evaluations on potential prodrugs and hybrid drugs with anti-proliferative effects. Chapter 1 gives an overview of current trends in cancer ... -
The effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The purpose of the research presented in this thesis was to produce metastable active pharmaceutical ingredients (API) by spray drying and to analyse, physico-chemically characterise these forms and develop strategies to ... -
The influence of drug physicochemical properties on release from thermoresponsive smart hydrogels
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Thermoresponsive hydrogels are a class of "smart" or "environmentally sensitive" systems with potential for controlling the release of a drug in response to a specific stimulus. Previous research in the area of thermoresponsive ... -
The pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)This study sought to determine the pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors (BuChEl’s) in vitro and in vivo. The potency of the novel compounds 2-benzylcarbamate 5-nicotinate ... -
The role of the community pharmacist in optimising patients' inhaler use in asthma management
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The Asthma Insights and Reality in Ireland survey revealed that only 8% of those surveyed had controlled asthma, as defined by evidence-based guidelines. A detailed analysis of patients’ abilities to use their inhalation ...