Browsing Genetics (Scholarly Publications) by Author "PALFI, ARPAD"
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Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
HUMPHRIES, PETER; PALFI, ARPAD; CHADDERTON, NAOMI SARAH; FARRAR, GWYNETH JANE; KENNA, PAUL (2012)Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ... -
Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
MILLINGTON-WARD, SOPHIA; O'REILLY, MARY; PALFI, ARPAD; KILTY, CLAIRE; HUMPHRIES, MARIAN; KENNA, PAUL; FARRAR, JANE; HUMPHRIES, PETER; CHADDERTON, NAOMI (2011)For dominantly inherited disorders development of gene therapies, targeting the primary genetic lesion has been impeded by mutational heterogeneity. An example is rhodopsin-linked autosomal dominant retinitis pigmentosa ...