Browsing Genetics (Scholarly Publications) by Author "Greene, Chris"
Now showing items 1-3 of 3
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Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders
Campbell, Matthew; Greene, Chris (2020)Major psychiatric disorders affect 25% of the population. While genetic and environmental risk factors have been identified, the underlying pathophysiology of conditions, such as schizophrenia, bipolar disorder and major ... -
Claudin-5: Gatekeeper of neurological function
Campbell, Matthew; Greene, Chris (2019)Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates ... -
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy
Campbell, Matthew; Greene, Chris (2021)Oligonucleotide therapies offer precision treatments for a variety of neurological diseases, including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB). Previous studies showed that intracerebr ...