Browsing Pharmaceutical Chemistry (Theses and Dissertations) by Author "Hughes, Rosario B."
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The design, synthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens
Hughes, Rosario B. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)This thesis is presented in four different sections. In the first section the synthesis of a number of structural (novel flexible) analogues of the antiestrogen drug tamoxifen is described. Preparation of novel conformationally ...