Browsing Pharmaceutical Chemistry (Theses and Dissertations) by Date of Publication
Now showing items 21-25 of 25
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Design and synthesis of 4-[1,3-diaryl-1H-pyrazole-4-yl]-2,6-dimethyl-1,4-dihydropyridine compounds and evaluation as anti-proliferative and multi-drug resistance reversal agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)1,4-Dihydropyridines are well known for their use as calcium channel blockers and are extensively used in treatment of hypertension. Dihydropyridine derivatives such as nifedipine have been shown to have the potential to ... -
Synthetic, photophysical and biological studies into new tools for investigating bile acid disposition and toxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The overall objective of this thesis was to use synthetic chemistry to provide tools to understand problems in bile acid research including their disposition and mechanism of toxicity. Fluorescent reporter groups are very ... -
Investigations of beta-lactams as novel bioactive compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)A natural stilbene product combretastatin A-4 (CA-4) is a known anti-cancer compound, which exerts its mechanism of action at the colchicine binding site on tubulin, a protein that is essential for the replication of cells. ... -
Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer is the second most common cancer in Ireland and accounts for 28% of all cancers in women in Ireland, with an average of 1726 new diagnosis each year. One of the major therapeutic advances in clinical treatment ... -
Dual acting nuclear receptor targeting conjugates : design, synthesis and biochemical evaluation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer has become the second most common cancer worldwide after lung cancer, the fifth most common cause of cancer death, and the foremost cause of cancer death in women. Worldwide, breast cancer exceeds all other ...