Browsing Oral Medicine (Theses and Dissertations) by Date of Publication
Now showing items 1-20 of 22
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Comparative genetic analysis of nosocomial methicillin-resistant Staphylococcus aureus populations in Ireland 1971-2004
(Trinity College (Dublin, Ireland). School of Dental Science, 2005)Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen responsible for nosocomial infections worldwide and Ireland has one of the highest rates of nosocomial MRSA infections in Europe. In the ... -
Development of differential media for Candida dubliniensis and identification of a novel clade of Candida dubliniensis predominant in the Middle East
(Trinity College (Dublin, Ireland). School of Dental Science, 2005)Candida dubliniensis is a newly described Candida species originally associated with oral colonisation and candidosis in Human Immunodeficiency Virus (HlV)-infected, and acquired immunodeficiency syndrome (AIDS) patients. ... -
Comparative growth analysis of Candida dubliniensis and Candida albicans in vitro and in selected infection models
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Candida dubliniensis is the species most closely related to C. albicans and is primarily associated with colonisation and oral candidiasis in Human Immunodeficiency Virus (HlV)-infected individuals and AIDS patients. Despite ... -
Comparative analysis of stress responses in C. albicans and C. dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Candida dubliniensis is apathogenic yeast that was first identified as a novel species in 1995. It is phylogenetically very closely related to C. albicans. However, despite the close relationship between the two species, ... -
A comparison of various methods of assessing salivary flow in normal and xerostomic subjects
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Saliva is produced by the three major paired salivary glands and minor salivary glands. Alterations in the quantity and quality of saliva have adverse effects on the oral cavity and influence patient quality of Hfe. How ... -
The efficacy of irradiation protocol and irradiation distance on resin-based composite performance
(Trinity College (Dublin, Ireland). School of Dental Science, 2008)The objective of the current study was to investigate the efficiency of the overlapping irradiation regime for resin-based composites (RBCs) in ISO 4049 by modifying the irradiation protocol. To exacerbate the potential ... -
A population structure analysis of Candida dubliniensis using multilocus sequence typing and an investigation of the molecular mechanism(s) of clade-specific resistance to 5-fluorocytosine
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis shares many phenotypic and genetic characteristics with its closest relative, Candida albicans, which most likely delayed the identification and subsequent classification of C. dubliniensis as a distinct ... -
An investigation into the relative adhesion of Candida dubliniensis and Candida albicans to human cells and extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis is a germ tube-positive, chlamydospore-producing yeast species originally recovered from the oral cavities of HIV-infected individuals and AIDS patients and first described in 1995. It is closely related ... -
Development of long-term practical solutions to the universal problem of biofilm contamination of dental unit waterlines
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Microbial contamination of dental chair unit (DCU) output water by biofilm growth in dental unit waterlines (DUWLs) is a universal problem and a potentially significant source of cross-infection. At the outset of this ... -
Effects of montmorillonite clay addition on the compressive fracture strength and wear resistance of glass-ionomer restoratives
(Trinity College (Dublin, Ireland). School of Dental Science, 2010)The aim of the present investigation was to investigate the influence of montmorillonite (MMT) clay, both as-found (un-modified calcium montmorillonite (Ca-MMT)) and pre-treated to encourage exfoliation (organically-modified ... -
Characterisation of Candida albicans populations associated with chronic hyperplastic candidosis (Candida leukoplakia) and non-Candida leukoplakia lesions in patients presenting with oral leukoplakic lesions in Ireland
(Trinity College (Dublin, Ireland). School of Dental Science, 2011)Oral squamous cell carcinoma is a significant global health problem, affecting about a half of a million people worldwide annually. Oral leukoplakic lesions have been reported to have significantly increased potential for ... -
Biocompatibility of non-precious dental casting alloys : development of novel testing mechanisms
(Trinity College (Dublin, Ireland). School of Dental Science, 2011)The aim of the present investigation was to investigate the biocompatibility potential of commercially available non-precious dental casting alloys facilitated by multiple analyses using a two-dimensional (2D) oral ... -
Comprehensive molecular characterisation of endemic and sporadic methicillin resistant Staphylococcus aureus recovered in Irish hospitals
(Trinity College (Dublin, Ireland). School of Dental Science, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a prevalent pathogen responsible for hospital- and community-acquired infections worldwide. Molecular typing of Irish MRSA isolates has revealed that different MRSA ... -
Molecular characterisation of Staphylococcus aureus and Staphylococcus epidermidis populations from healthy and diseased oral implant and natural tooth sites in a cohort of patients with periimplantitis
(Trinity College (Dublin, Ireland). School of Dental Science, 2013)The majority of STs (19/22, 86.36%) belonged to the predominant clonal complex CC1. In comparison to the global S. epidermidis MLST database, the STs identified in this study exhibited no enrichment of or particular ... -
High-throughput DNA microarray characterisation and molecular analysis of resistance to mupirocin, fusidic acid and linezolid in Methicillin-Resistant Staphylococcus aureus : populations in Irish hospitals 1971-2010
(Trinity College (Dublin, Ireland). School of Dental Science, 2013)Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen of humans and animals and can express multiple virulence and antimicrobial resistance genes. In Ireland, detailed molecular typing showed that different ... -
The strengthening of resin cemented dental ceramic materials
(Trinity College (Dublin, Ireland). School of Dental Science, 2013)The aim of the current investigation was to advance the understanding of the mechanism of resin-strengthening conferred to dental ceramic materials by resin-based composite materials. The investigation is presented as a ... -
The telomere-associated (TLO) genes of Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Candida species are members of the Saccharomycetuceae and are the most common cause of fungal infections in humans. Diseases caused by these yeasts range from superficial infections (e.g. oropharyngeal & vulvovaginal ... -
Molecular typing of Methicillin-resistant and Methicillin-susceptible Staphylococcus aureus and Coagulase-negative staphylococci recovered in Irish hospitals and characterisation of SCCmec and SCCmec-containing composite islands
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Methicillin-resistant Staphylococcus aureus (MRSA) are a major cause of infections in animals and humans. The methicillin resistance gene mecA is located on a mobile genetic element termed the staphylococcal cassette ... -
The role of hyphae and hypha-associated genes in the pathogenesis of Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Candida albicans is a major cause of superficial and systemic fungal infections in humans. In contrast, its most closely related phylogenetic neighbour, Candida dubliniensis, causes disease much less frequently, despite ... -
Functional analysis of the TLO gene family in Candida albicans and Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2015)
