Browsing Psychiatry (Scholarly Publications) by Title
Now showing items 21-40 of 361
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An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
(Nature Publishing Group, 2008)The recent completion of the International HapMap Project has rapidly advanced our understanding of linkage disequilibrium (LD) in the human genome. Today, tagging SNPs (tSNPs) can be quickly and easily selected and ... -
Association between dopamine transporter (DAT1)genotype, left sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder
(2005)A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the ... -
Association of serotonin and dopamine gene pathways with behavioural subphenotypes in dementia.
(2012)Genetic association studies investigating the association between genes of serotonergic and dopaminergic systems and behavioral and psychological symptoms in dementia (BPSD) are contradictory. We have utilized 1008 probable ... -
Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases
(1999)Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes ... -
The autism brain imaging data exchange: Towards a large-scale evaluation of the intrinsic brain architecture in autism
(2014)Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires ... -
Autism spectrum disorder genomics: The progress and potential of genomic technologies
(2020)Genomic technologies have accelerated research progress in autism spectrum disorder (ASD) genomics and promises to further transform our understanding of the genetic basis of this neurodevelopmental disorder. Here we review ... -
Autistic Tendencies: The Consequences for Our Culture
(2006)Professor Michael Fitzgeraldtalks withJoe Griffinabout the powerful impact, both positive and negative, of autistic thinking in diverse walks of life. -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
(2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Bio-collections in autism research.
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Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants.
(2014)Objective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share ... -
Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
(2019)Introduction: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)–targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies ... -
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity ... -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
(2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach
(2014)Background Category fluency is a widely used task that relies on multiple neurocognitive processes and is a sensitive assay of cortical dysfunction, including in schizophrenia. The test requires naming of as many words ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ...