Psychiatry (Theses and Dissertations): Recent submissions
Now showing items 1-20 of 73
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Mental Capacity for Treatment Decisions in Psychiatry Inpatients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)This research aimed to assess the prevalence of mental capacity for treatment decisions in psychiatry inpatients in Ireland and elucidate the relationship, if any, between mental capacity and key clinical and demographic ... -
Exploring Neurocognitive Factors Underlying Autism and Hyperphagia in Prader-Willi Syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Background: Prader-Willi Syndrome (PWS) is a rare complex multisystem genetic disorder recognised as the most common genetic cause of life-threatening obesity in humans (Butler, 1996). The PWS genotype gives rise to a ... -
Long-term outcomes following electroconvulsive therapy for treatment-resistant depression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)Background: Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression but its use is limited by high rates of early relapse and retrograde amnesia of uncertain severity and duration. Aims: ... -
Limbic System Development in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Longitudinal Multimodal MRI Analysis
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)While Attention-Deficit Hyperactivity Disorder (ADHD) is characterized by age-related changes in symptoms and brain structures during childhood and adolescence, the link between brain structure and function is less clear. ... -
Deep Learning for Neuroimaging: Advancing Brain-Based Biomarkers of Autism Spectrum Disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)In the last decade, deep learning (DL) has revolutionised fields like speech and vision through artificial neural networks. Can DL similarly transform biological psychiatry and neuroimaging? This thesis explores that ... -
The Contribution of Additional Genetic Variation to CNV Carrier Cognitive and Neurodevelopmental Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Many copy number variants (CNV) are strongly associated with neurodevelopmental disorders (NDDs) such as autism, intellectual disability/developmental delay (ID/DD) and schizophrenia. CNVs are large genomic deletions or ... -
Coercion and Involuntary Care: A Study of Involuntary and Voluntary Psychiatry Inpatients in Dublin
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Involuntary care is a feature of mental health services around the world. In addition to involuntary admission and treatment, specific coercive or restrictive practices including seclusion and physical restraint occur in ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
BRAIN: Brain Injury in Neonates
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Despite advances in neonatal care leading to a dramatic reduction in mortality rates in recent decades, there have been comparatively modest improvements in neurodevelopmental outcomes for infants born with neonatal ... -
The Molecular Mechanisms of rhIGF1 in the Treatment of Rett Syndrome and Related Disorders: Studies in Patients, Mouse and Cellular Models
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Recombinant human Insulin-like Growth Factor 1 (rhIGF1) is an approved treatment for growth failure and IGF1 deficiency. IGF1 has multiple functions in the body including growth, cell survival, metabolism, ageing and ... -
Ancestral Legacies of an Insular Archipelago: A genomic exploration of prehistoric Japan and mainland Asia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The objective of this thesis is to use ancient genomic data and a variety of bioinformatic approaches to explore human evolutionary history in the Japanese archipelago and mainland Asia. This thesis presents a dense genomic ... -
Perinatal Depression and Children's Developmental Outcomes at 2 and 3 Years Postpartum
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Depression is the most common perinatal psychiatric disorder and has been associated with a range of adverse outcomes for children, parents and overall family functioning. The current thesis sought to build on existing ... -
India's Mental Healthcare Act, 2017 Evaluation of the Act, its Context and Initial Implementation
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The United Nations has initiated a paradigmatic shift in mental healthcare through the United Nations Convention on the Rights of Persons with Disabilities (CRPD), in addition to this the WHO has identified legislation as ... -
Investigating clinically relevant phenotypes of neurodevelopmental copy number variants in Children and Adults
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2021)Background: Neurodevelopmental copy number variants (ND CNVs) present with clinically pleiotropic effects, transcending psychiatric diagnostic borders. Gaining clarity on the neurodevelopmental and psychiatric phenotypic ... -
Structural Changes of Brain Areas Involved in Emotion and Memory Processing across Lifespan
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)People are defined by their genes, familiar background and personal experiences, that can have either a negative or positive impact. Altogether, this represents and shapes their decisions, behaviours and relationships with ... -
Exploring the molecular mechanisms of Rett syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Rett Syndrome (RTT) is a severe neurological disorder that onsets between 6 to 18 months of age, after a period of apparently normal development. RTT affects approximately 1 in every 10000 to 15000 live births and is ... -
Molecular pathways of depression and antidepressant therapies for treatment resistant depression
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)According to the World Health Organisation, depression is the most common psychiatric disorder. Despite this, the pathophysiology of depression is unclear. Electroconvulsive therapy (ECT) is the most acutely effective ... -
Assessing the effects of coenzyme QIO in schizophrenia & schizoaffective disorder: a randomised, placebo controlled trial
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Background: Schizophrenia is a complex, heterogeneous, neurodevelopmental disorder. Cognitive impairments and negative symptoms such as avolition and asociality are prevalent in the majority of patients with a diagnosis ...