Browsing Physiology (Scholarly Publications) by Author "Lynch, Marina"
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Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
Lynch, Marina; Kelly, Aine; Mills, Kingston (2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
Kerskens, Christian; Lynch, Marina; Kelly, Aine (2012)In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures ... -
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
Lynch, Marina; Lynch, Aileen; Kelly, Aine; O'Neill, Luke (2001)Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these ... -
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
Lynch, Marina; Finucane, Orla; Rubio-Araiz, Ana; Keogh, Samuel (2018)Background: Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with ... -
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
Lynch, Marina; Downer, Eric; Johnston, Daniel (2013)Accumulating evidence continues to underpin the role of the innate immune system in pathologies associated with neuroinflammation. Innate immunity is regulated by pattern recognition receptors that detect pathogens, and ... -
Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
Lynch, Marina (2022)One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ... -
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
Lynch, Marina; Kerskens, Christian; McIntosh, Allison; Mela, Virginia; Harty, Conor; Minogue, Aedin M.; Costello, Derek A.; Kerskens, Christian; Lynch, Marina A. (2019)Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide ... -
Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming.
Lynch, Marina; Lawlor, Brian (2019)The search for a blood-based biomarker that identifies Alzheimer’s disease (AD) and can replace current invasive and expensive diagnostic tests, continues. The most extensively-examined peripheral marker is β-amyloid (Aβ) ... -
The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages
Lynch, Marina; Finucane, Orla; Guillot-Sestier, Marie-Victoire (2019)Infammation and metabolism are intricately linked during infammatory diseases in which activation of the nucleotide-binding domain–like receptors Family Pyrin Domain Containing 3 (NLRP3) infammasome, an innate immune ...