Browsing Pharmacology & Therapeutics (Scholarly Publications) by Author "KLYUBIN, IGOR"
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Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo.
ROWAN, MICHAEL; KLYUBIN, IGOR (2013)Abstract BACKGROUND: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer's disease (AD)-associated amyloid β-protein (Aβ). ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
ROWAN, MICHAEL; ANWYL, ROGER; KLYUBIN, IGOR; HU, NENG (2010)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.
KLYUBIN, IGOR; ROWAN, MICHAEL (2011)A role for PrP in the toxic effect of oligomeric forms of A?, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ...