Surgery (Theses and Dissertations): Recent submissions
Now showing items 1-5 of 34
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3D Bioprinting of Anatomically Accurate Implants for Meniscus Tissue Engineering
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Menisci are soft tissues essential for load bearing and stress distribution in the knee joint. Meniscal injuries are common in all age groups and can lead to degeneration of the joint. While currently available surgical ... -
Investigating the impact of body composition and nutritional intervention strategies in pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Introduction: Pancreatic adenocarcinoma (PDAC), while often described a rare or neglected cancer, is the fourth cause of cancer-related mortality in the US and Europe. Unintentional weight loss is a prominent feature of ... -
Oesophageal cancer : association with visceral obesity, inflammation and optimisation of postoperative outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)The incidence of oesophageal cancer is rising in the developed world and has paralleled the rising prevalence of obesity. This is an aggressive malignancy with poor overall survival rates. Thus there is an impetus to ... -
Enhancing treatment response to neo-adjuvant radiation therapy in oesophageal cancer using novel dual action drugs targeting tumour energy metabolism and angiogenesis
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2019)Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ... -
Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ...
