dc.contributor.author | Wetterling, Friedrich | |
dc.date.accessioned | 2024-04-29T08:46:51Z | |
dc.date.available | 2024-04-29T08:46:51Z | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Sack M, Wetterling F, Sartorius A, Ende G, Weber-Fahr W, Signal-to-noise ratio of a mouse brain (13) C CryoProbe system in comparison with room temperature coils: spectroscopic phantom and in vivo results., NMR in biomedicine, 27, 6, 2014, 709-15 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/108313 | |
dc.description | PUBLISHED | en |
dc.description.abstract | MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that for (1) H nuclei, an even larger sensitivity improvement is expected for (13) C applications. The aim of this work was to evaluate the performance of a prototype (13) C CryoProbe™ for mouse brain MRS. To investigate the possible gain of the (13) C CryoProbe™, we acquired localized single-voxel (13) C spectra and chemical shift images of a dimethyl sulfoxide phantom with the CryoProbe™, as well as with two room temperature resonators. The cryogenically cooled resonator achieved approximately four-fold higher signal-to-noise ratio in phantom tests when compared with the best-performing room temperature coil. In addition, we present localized (13) C spectra of mouse brain obtained with the CryoProbe™, as well as with one of the room temperature coils, demonstrating the performance in vivo. In summary, the cryogenic cooling technique significantly enhances the (13) C signal sensitivity at 9.4 T and enables the investigation of metabolism within mouse brain. | en |
dc.format.extent | 709-15 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | NMR in biomedicine; | |
dc.relation.ispartofseries | 27; | |
dc.relation.ispartofseries | 6; | |
dc.rights | Y | en |
dc.subject | 13C spectroscopy; CryoProbe™; MRS; SNR comparison; cryogenic coil; mouse | en |
dc.title | Signal-to-noise ratio of a mouse brain (13) C CryoProbe system in comparison with room temperature coils: spectroscopic phantom and in vivo results. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/wetterf | |
dc.identifier.rssinternalid | 96607 | |
dc.identifier.doi | http://dx.doi.org/10.1002/nbm.3110 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Neuroscience | en |
dc.subject.TCDTheme | Next Generation Medical Devices | en |
dc.identifier.rssuri | http://onlinelibrary.wiley.com/doi/10.1002/nbm.3110/abstract | |