Quantitative 23Na-MRI: From Pre-Clinical to Clinical Practice
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Friedrich Wetterling, Judith Kisubi, Eva Haardt, Simon Konstandin, Armin Nagel, Marc Fatar, Eva Neumaier-Probst, Lothar R. Schad, Quantitative 23Na-MRI: From Pre-Clinical to Clinical Practice, 41st annual meeting of the German Association for Medical Physics (DGMP), Freiburg, Germany, 41, 2010, 1Abstract:
Quantitative 23Na-MRI (qNa-MRI) is a non-invasive technique which allows for measuring subtle changes in the Tissue
Sodium Concentration (TSC) after ischaemic stroke. Although, an increase in TSC after stroke has been reported many times
in the literature [1-5] the underlying mechanisms related to the regionally TSC changes have only recently been investigated
in an animal stroke model. The in vivo TSC time-course data revealed that the time point at which the TSC started to
increase varied significantly in still viable (penumbra) and permanently damaged (core) tissue [6]. A threshold at normal
TSC level could consequently serve to differentiate between penumbra and core tissue after stroke. However, the TSC has
never been studied during the acute stroke phase in humans (<6h after Onset) due to the challenges involved in adding qNaMRI to the standard 1H-MRI protocol. The aim of this study was to develop a comprehensive stroke protocol for 1H and
23Na MRI of acute stroke patients at 3T.
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PUBLISHEDFreiburg, Germany
Author: Wetterling, Friedrich
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41st annual meeting of the German Association for Medical Physics (DGMP)Type of material:
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