Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
Citation:
Jean Dunne, 'Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2002, pp 248Download Item:
Abstract:
Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists of prolonged fever, failure to thrive, irritability, and hepatosplenomegaly (Henter et al. 1991a). Parental consanguinity indicated a diagnosis of familial haemophagocytic lymphohistiocytosis (FHL) in the case of patient A. Following the development of an Epstein-Barr virus (EBV)-driven lymphoma the diagnosis of patient B was altered to EBV-lymphoma associated haemophagocytic syndrome (EBV-LAHS). The two young patients lacked NK cells and had reduced CD8+ T cells at presentation. They both suffered from recurrent infections most notably with Herpes family viruses.
Author: Dunne, Jean
Advisor:
Feighery, ConlethQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ImmunologyNote:
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Full text availableKeywords:
Immunology, Ph.D., Ph.D. Trinity College DublinMetadata
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