Browsing Obstetrics & Gynaecology by Date of Publication
Now showing items 1-20 of 22
-
Uteroplacental fibrinolysis in normal pregnancy, preeclampsia and intrauterine growth retardation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2000)Normal pregnancy is accompanied by extensive changes in the coagulation and fibrinolytic systems. Within the uteroplacental vasculature decidual spiral arteries undergo extensive morphological changes to allow for increased ... -
Prediction of pre-eclampsia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2003)Pre-eclampsia occurs in 2-10% of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. The serious shortcoming associated with management is that the underlying aetiology is unknown. To date ... -
Predicting the response of gynaecological tumours to chemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2003)The aim of this study was to use an in vitro (3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) (MTS) assay in combination with an explant culture technique to determine ... -
Potential role of miR-9 and miR-223 in recurrent ovarian cancer
(2008)Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable ... -
The influence of inherited thrombophilia, endothelial activation and fibrinolysis on placental morphology and vasculature and on maternal and fetal outcome, in a low risk primigravid population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2009)A number of inherited thrombophilias have been associated with adverse events occurring during pregnancy. A common feature of these abnormalities is their ability to alter endothelial function and to increase thrombin ... -
Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.
(2009)Background: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the ... -
Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens
(Elsevier, 2010)Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their ... -
Oxytocin bolus versus oxytocin bolus and infusion for control of blood loss at elective caesarean section: double blind, placebo controlled, randomised trial.
(2011)OBJECTIVES: To determine the effects of adding an oxytocin infusion to bolus oxytocin on blood loss at elective caesarean section. DESIGN: Double blind, placebo controlled, randomised trial, conducted from February 2008 ... -
Methadone use in pregnancy : prevalence and pregnancy outcomes in an Irish obstetric cohort
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2011)This thesis aimed to address current knowledge deficits relating to the issues of medication use in early pregnancy in an Irish healthcare setting and adverse perinatal outcomes in opioid-dependent pregnant women on methadone ... -
Phytoestrogens as an alternative to HRT : an investigation into the molecular effects of phytoestrogens on haemostasis in cell and animal models
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2011)There is a direct link between the increased risk of cardiovascular disease and the menopause and this is thought to be due to the progressive lack of endogenous oestrogen in post-menopausal women. Observational studies ... -
Control of blood loss at caesarean section
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2011)Caesarean section is one of the most commonly performed major operations in women throughout the world. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value ... -
Study protocol. IDUS - Instrumental delivery & ultrasound: a multi-centre randomised controlled trial of ultrasound assessment of the fetal head position versus standard care as an approach to prevent morbidity at instrumental delivery.
(2012)Background Instrumental deliveries are commonly performed in the United Kingdom and Ireland, with rates of 12 – 17% in most centres. Knowing the exact position of the fetal head is a pre-requisite for safe instrumental ... -
Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes--a prospective cohort study.
(2013)Background There has been limited research addressing whether behavioural change in relation to alcohol exposure in pregnancy results in better perinatal outcomes. Methods A cohort study of 6725 women who booked for ... -
A retrospective cohort study of mode of delivery among public and private patients in an integrated maternity hospital setting.
(2013)Abstract Objective To examine the associations between mode of delivery and public versus privately funded obstetric care within the same hospital setting. Design Retrospective cohort study. Setting Urban maternity ... -
Population-Based Study of Smoking Behaviour throughout Pregnancy and Adverse Perinatal Outcomes.
(2013)There has been limited research addressing whether behavioural change in relation to smoking is maintained throughout pregnancy and the effect on perinatal outcomes. A cohort study addressed lifestyle behaviours of 907 ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
(2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ... -
Ultrasound to enhance assessment of the fetal head position prior to instrumental delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2013)This thesis is aimed at investigating the role of ultrasound to enhance diagnosis of the fetal head position prior to instrumental delivery in order to make instrumental deliveries safer.There are four components to this ... -
A prospective cohort study of alcohol exposure in early and late pregnancy within an urban population in Ireland
(2014)Most studies of alcohol consumption in pregnancy have looked at one time point only, often relying on recall. The aim of this longitudinal study was to determine whether alcohol consumption changes in early and late pregnancy ...