Browsing Obstetrics & Gynaecology by Author "Kelly, Lynne"
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Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens
Norris, Lucy; O'Leary, John; Kelly, Lynne (Elsevier, 2010)Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their ... -
Phytoestrogens as an alternative to HRT : an investigation into the molecular effects of phytoestrogens on haemostasis in cell and animal models
Kelly, Lynne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2011)There is a direct link between the increased risk of cardiovascular disease and the menopause and this is thought to be due to the progressive lack of endogenous oestrogen in post-menopausal women. Observational studies ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
Norris, Lucy; Martin, Cara; O'Leary, John; Finn, Stephen; O'Toole, Sharon; Sheils, Orla; Abu Saadeh, Feras; Flavin, Richard; Kelly, Lynne (2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ...