Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
Citation:
Vincent O'Reilly, 'Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2013, pp 256Download Item:
Abstract:
Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and infection in numerous murine models of disease. Based on the very promising results observed in murine models, clinical trials have been undertaken with cancer patients, but to date have been somewhat disappointing. The best results were obtained using a combination therapy of adoptively transferred dendritic cells (DC) pulsed with the prototypical iNKT cell ligand, alpha galactosylceramide (aGalCer) along with ex vivo expanded iNKT cells.
Author: O'Reilly, Vincent
Advisor:
Doherty, DerekQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ImmunologyNote:
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Full text availableKeywords:
Immunology, Ph.D., Ph.D. Trinity College DublinMetadata
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