A characterisation of cyclooxygenase activity in synaptic transmission and plasticity in the Hippocampus
Citation:
Thelma R. Cowley, 'A characterisation of cyclooxygenase activity in synaptic transmission and plasticity in the Hippocampus', [thesis], Trinity College (Dublin, Ireland). School of Psychology, 2006, pp 194Download Item:
Abstract:
We used in vivo electrophysiological techniques to investigate the role played by cyclooxygenase (COX) enzymatic activity in synaptic transmission and plasticity. The use of selective pharmacological antagonists for the COX-1 and COX-2 isoforms enabled us to differentiate the functions of these two very similar enzymes in the dentate gyrus of the hippocampal formation, using a model of memory storage - long¬term potentiation (LTP). This is a process whereby repeated firing of neurons by tetanic stimulation results in an increase in synaptic efficacy and a change in synaptic weights. It is this change in synaptic weight that is postulated to underlie memory storage. We have shown that exogenous replacement of a metabolite of COX activity, PGE2, directly into the hippocampus was sufficient to reverse the effects of the antagonism.
Author: Cowley, Thelma R.
Advisor:
O'Mara, ShaneQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of PsychologyNote:
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Full text availableKeywords:
Psychology, Ph.D., Ph.D. Trinity College DublinMetadata
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