Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
Citation:
Greg Byrne, 'Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2006, pp 227Download Item:
Abstract:
Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous atrophy, crypt hyperplasia and increased levels of mononuclear cells in the epithelium and lamina propria. Although coeliac disease is one of the best characterised complex diseases, the mechanisms leading to the associated mucosal pathology are not well understood. A related gluten-sensitive disorder called dermatitis herpetiformis is characterised by a bullous skin rash caused by IgA deposits at the dermal-epidermal junction and a milder intestinal lesion.
Author: Byrne, Greg
Advisor:
Kelly, JacintaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ImmunologyNote:
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Full text availableKeywords:
Immunology, Ph.D., Ph.D. Trinity College DublinMetadata
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